- Black Matters: A Teach-In On Language, Literature, Rhetoric, Writing, and Verbal Art Collection (Ms2020-006)
- A. J. Davis Family Collection (Ms2012-067)
- Association for the Preservation of Virginia Antiquities, Montgomery County Branch Papers
- Biographical Vertical Files
- Black Excellence in STEM Oral History Project (Ms2024-072)
- Charles Aliff Railroad Collection
- Charles Goodsell Collection, 1982-2001, (Ms2004-012)
- Christiansburg Industrial Institute Oral History Project (Ms2019-037)
- Civil War Small Manuscripts Collection
- Company E Class of 1967 Digital Photograph Collection
- Danville Community College / VPI Extension
- Drake Railroad Collection
- Ellison A. Smyth. Sr. Papers, 1859-1927, (Ms1981-098)
- G. Preston Frazer Artwork, 1940-1953, (Ms1992-055)
- German Club Dance Cards, c. 1910 - c. 2001
- Henry Flippen Turner Collection
- Historical Photograph Collection
- History of Food and Drink
- Larry McBryde Collection on the John McLaren McBryde Family, 1859-1920s, (Ms2013-024)
- Manuscript Collections
- Blacksburg Woman's Club Records
- Colonel William Christian Chapter, National Society of the Daughters of the American Revolution Records
- Cynthia Addington Boatwright Papers
- J. A. Snavely Letter, 1899 (Ms2013-040)
- Jacob Cassel Papers, 1865-1881 (Ms2008-086)
- Jaffe-Lankes Family Correspondence, 1930-1942, 1980-1985 (Ms2019-014)
- James T. Farrell Letters to Eleanor Copenhaver Anderson, 1952, 1954 (Ms2017-005)
- Jimmie W. Monteith, Jr. Collection, 1933-1997 (Ms1990-062)
- Keystone View Company Papers (Ms2010-052)
- Landon Duncan Letters, 1812-1837 (Ms1997-023)
- Leonard A. Slater Letter, 1862, Ms2011-052
- Lucy Herndon Crockett Papers (Ms2011-032)
- Marjorie Rhodes Townsend Papers (Ms1986-003)
- Mary Sinton Leitch Correspondence with J. J. Lankes, 1932-1950 (Ms2017-001)
- Montgomery Female College Collection, 1875-1892 (Ms2009-013)
- Patricia Givens Johnson Papers
- Sherwood Anderson Collection, 1912-1938 (Ms1973-002)
- Sherwood Anderson Correspondence with Llewellyn Jones, 1916-1924, n.d. (Ms2015-044)
- Sherwood Anderson Photograph and Postcard, 1929, 1939 (Ms2011-004)
- Watercolors of Fungi (Ms1993-012)
- Welford D. Taylor Collection on Sherwood Anderson, 1918-2006, n.d. (Ms2015-020)
- Yonson (Johnson) Family Collection, 1803-1859 (Ms2013-080)
- Norfolk and Western Construction Photographs
- Norfolk and Western Historical Photograph Collection
- Norfolk and Western Railroad Co., Time Table No. 6
- Norfolk and Western Railroad Photograph Negatives
- O. Gaines Whitley, Sr., Photograph Albums (Ms1995-021)
- Oral History Clips: April 16, 2007
- Oral History Clips: Graduate Life Center
- Phyllis Keith Railroad Photographs
- Printed Materials
- Record Group Vertical Files
- Regional History and the Appalachian South
- African-American Tenant Farmer Photographs, Clarksville, Va., c. 1920-1930 (Ms2009-110)
- Black Appalachians Oral History Project (Ms1991-019)
- Black, Kent, and Apperson Family Papers, 1779-1984 (Ms1974-003)
- Blacksburg [Virginia] Odd Fellows Records, 1902-1969 (Ms1988-009)
- Catlett Conway Correspondence, 1892-1920 (Ms2012-039)
- Charles M. and Nancy G. Figgat Letters (Acc2019-132)
- Charles M. Figgat[t] Letters (Acc2020-006)
- Charlotte D. Gale Photograph Album (Ms1990-044)
- Cordie Cheek Papers, 1933-1934 (Ms1987-026)
- Crockett Mineral Springs Collection, 1930-1931 (Ms2009-105)
- Croy Family Papers, 1859-1938 (Ms2001-018)
- Croy Family Photographs (Digital Images related to Croy Family Papers, Ms2001-018)
- Dale Belcher Photographs (Ms1997-021)
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880-1989 (Ms1989-025)
- Elizabeth Kent Adams Papers, 1922 - 1987 (Ms1990-045)
- Fries Textile Mill Oral Histories 2019-2022 (Ms2019-045)
- Fries Textile Plant Records, 1900-1988 (Ms1989-039)
- Harold S. Hill Collection (Ms2007-001)
- History of New Town
- Huff-Hylton Families Papers, 1803-1816, 1858-1882, 1975, n.d (Ms1998-001)
- J. Hoge Tyler Family Collection, 1802-1956 (Ms1967-002)
- James E. Yates Account Book (Ms1940-032)
- James J. Pandapas Audiotape and Papers, 1966-1988, 1997 (Ms1997-011)
- James Longstreet Correspondence (Ms1993-003)
- John T. Cowan Papers, 1887-1917 (Ms1969-005)
- Lucy Dickinson Urquhart Papers, 1865-1973 (Ms1987-046)
- M. Rupert Cutler Papers (Ms2020-005)
- Nelson Family Papers, 1783-1872 (Ms1989-021)
- Newport and Clover Hollow, Giles County History Collection, 1904, 1973-2006 (Ms2013-086)
- Piedmont Tuberculosis Sanatorium (Burkeville, Virginia) Collection
- Postcards from Appalachia (Ms2015-032)
- Preston Family Correspondence, 1861, 1872 (Ms2010-070)
- Rick Boucher Papers (Ms2021-048)
- Shell Family Papers, 1871-1932 (Ms1959-001)
- Smithfield Preston Foundation Papers, 1784-1881, n.d. (Ms1997-002)
- Solitude Exhibit Materials
- Solitude Photographs and Papers, ca. 1960s-1980s (Ms1993-024)
- Squire Bosworth Papers, 1848-1892 (Ms2010-060)
- Virginia Republican Party Flyer
- Roanoke Railway and Electric Company Photo Album
- Science and Technology
- Sheet Music Collections
- Slaveship "Elizabeth" Records, 1750 (Ms1974-001)
- Smithey & Boynton, Architects and Engineers Records
- The American Civil War
- Alexandria and Fairfax Counties [Virginia] Civil War Correspondence, 1861-1862 (Ms2013-029)
- Allison Family Correspondence, 1862-1864 (Ms2011-060)
- Archibald Atkinson Jr. Memoir (Ms1994-022)
- Bear Family Papers (Ms1992-010)
- Benjamin Franklin Butler Notebook (Ms1990-060)
- Civil War Diaries
- Edgar Knapp Letters, 1862-1864 (Ms2002-015)
- Elden E. Billings Collection (Ms1991-036)
- Everett and Warren Hutchins Papers (Ms2009-014)
- Fenner Wilson Letter, 1863 (Ms1988-082)
- Fenwick Civil War Materials Collection, 1861-1865 (Ms2001-042)
- G. Horace Tarr Letter, 1863 (Ms1987-028)
- George F. Doyle Scrapbook (Ms1989-096)
- Great Seal of the Confederate States of America, ca. 1872-1874 (Ms2017-022)
- Henry C. Carpenter Letters, 1862-1864 (1996-008)
- Herbert E. Valentine Scrapbook (Ms1995-027)
- Hiram Matthew Papers, 1863-1865 (Ms1988-090)
- Homer E. Davis Papers (Ms2001-051)
- Isaac White Letters, 1861-1938 (Ms1997-013)
- Isaiah Conley Civil War Correspondence and Research Materials, 1862-2000s (Ms2015-051)
- Jacob S. Winans Correspondence, 1861 (Ms2015-062)
- James Francis Heizer & Phoebe Anne McCormick Heizer Collection, 1861-1868 (Ms2016-013)
- James P. Hawkins Papers (Ms2008-025)
- James R. Tice Letters (Ms2003-006)
- James W. M. Harris Papers, 1857 - 1900, (Ms2000-085)
- John C. Watkins Letters, Ms2009-071
- John Henning Woods Papers, 1856-1873 (Ms2017-030)
- John N. Hull Letter 1863 (Ms1992-043)
- John Newton Carnahan Letters (Ms2009-112)
- Joseph T. Harris Correspondence, 1861-1862 (Ms2018-016)
- Key Family Papers, 1812-1904 (Ms1992-044)
- Lee Hendrix Correspondence, 1862-1863 (Ms1990-020)
- Lewis Wood Letters, 1862-1863 (Ms1991-011)
- Nancy (Nannie) G. Figgat Correspondence, 1863 (Ms2012-080)
- Robert E. Lee Collection, 1866-1870 (Ms2002-044)
- Robert Edmiston Inventory, 1815 (Ms1988-077)
- Robert Taylor Preston Papers (Ms1992-003)
- Sephas (Cephas) L. Walton Correspondence, 1861-1865, 1884 (Ms1955-001)
- Silas H. Stepp Letters (Ms1992-020)
- Smith Family Letters, 1861-1865, 1912-1996, n. d. (Ms1996-018)
- Stanford E. Chaillé Collection, 1860-1903 (Ms2008-031)
- The Koontz Family Papers (Ms1984-172)
- William A. Leonard Papers, 1864-1865 (Ms2011-106)
- William H. Yeaman Papers, 1862-1863 (Ms2010-034)
- William L. Scott Letter, 1863 (Ms1988-085)
- William Latham Candler Papers, 1861-1863 (Ms1997-007)
- The McCormick Farm Museum Photographs
- University History and Archives
- Anti-Asian Panic and the Pandemic: A Virtual Teach-In Collection (Ms2020-003)
- Bugles
- Minority Newsletter and Diversity News
- Techgram
- The Tin Horn
- Virginia Tech Conductor: AGuide for Our Journey toward Excellence, Equity and Effectiveness
- Virginia Tech Spectrum
- 125th Anniversary of Virginia Tech Collection
- 150th Anniversary of Virginia Tech Collection
- Adam T. Finch Collection, 1891-1933, (Ms1974-015)
- Alice
- Bailey-Law Collection, 1825-1971, (Ms1982-002)
- Black History at Virginia Tech
- Black Women at VT Oral History Project (Ms1995-026)
- Byron Nelson Cooper Papers, 1925-1971 (Ms1973-004)
- Campus Panoramic Photographs, 1995-2000
- Department of Biochemistry Oral History Collection (Ms2003-009)
- Doug Burton Papers (Ms2020-001)
- Harry Downing Temple Jr., Papers, 1872-2004 (bulk, 1930-2001) (Ms1988-039)
- Hermann C. Niemeyer Papers (Ms1987-062)
- Hokie Birds - Gobble de Art
- Insurance Survey of Virginia Polytechnic Institute Records, 1931 (Ms1995-029)
- Karl Jacob Belser Illustrations, 1931-1932, (Ms1956-003)
- LGBTQ History at Virginia Tech
- Marching Virginians' April 16, 2007 Condolence Collection
- Mary Josephine Hartwick VPI Memorabilia and Scrapbook, 1924-1925 (Ms2013-009)
- Multicultural Diversity Oral History Project (Ms2002-001)
- Photographs from the Beulah O. Allen Collection (Ms2014-002)
- Records of the Virginia Tech Board of Visitors (RG 1)
- Sesquicentennial Time Capsule Collection (Ms2022-089)
- Student Government Association Records (RG 31/16)
- Virginia Tech Course Catalogs
- Virginia Tech Vice Presidents Oral History Project Collection (Ms2024-082)
- VT Stories Oral History Collection (Ms2016-015)
- William MacFarland Patton Papers, 1896 (Ms1954-001)
- University Songs Record Group, n.d., (RG 40/8)
- Virginia Cooperative Extension Photographs, 1937-1966 (RG.26.02B)
- Virginia Tech April 16, 2007 Archives of the University Libraries (MS2008-020)
- Virginia Tech Corps of Cadets Museum
- Voces of a Pandemic Oral History Collection (Ms2021-023)
- VPI Film Vault
- Wake Forest Community Cemetery Collection, 2001, (Ms2002-033)